Aversive and Reinforcing Opioid Effects

I’m glad to see this. There’s more behind “drug liking,” and I hope to see it surface in the literature. In fact, I think the work might have already been done. You might know of it.

My curiosity was initially piqued by conversations I had with addicts who told me that the first time they took an opioid pill, it was as if they felt like their genuine self for the first time. They had always felt somehow empty, incomplete, uncomfortable in their own skin, and then they broke their toe or something and got some Percodan and, wow! The lights came on in color. And their lives ever since kind of revolved around keeping that going.

So I made the assumption that this subclass of homo sapiens must have a genetic problem in the endogenous oipiate department, felt sorry for them because they couldn’t for some reason get that amazing rush and long-lasting well-being that I got from running, and forgot about it until the recent out of control lunacy.

I do believe there are people who really can’t produce their own endogenous opiates. What a misery! I can’t imagine.

I hope the science will be better understood so that these people can be treated for their medical needs without being stigmatized, abused, marginalized, punished….

EDS and Chronic Pain News & Info

Aversive and Reinforcing Opioid Effects: A Pharmacogenomic Twin Study | Anesthesiology. 2012 Jul | Free Full-text PMC article

The clinical utility of opioids is limited by adverse drug effects including respiratory depression, sedation, nausea, and pruritus. In addition, abuse of prescription opioids is problematic.

Gaining a better understanding of the genetic and environmental mechanisms contributing to an individual’s susceptibility to adverse opioid effects is essentialto identify patients at risk.

While more and more studies are showing how frequently and thoroughly genetic differences affect patients, the CDC is denying all this science to arrive at arbitrary “standard” doses of opioids.

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